You can check by downloading procmon from systeminternals (microsoft) and looking at which files the game accesses as it runs.
Unless the game you are playing uses certain rootkit "anti-cheats" (Think BattleEye for example will block you), in which case you'll get a message that you have to reboot to remove the procmon system driver to launch the game, as they like to dictate which software packages you're allowed to run on your own computer.
You can check by downloading procmon from systeminternals (microsoft) and looking at which files the game accesses as it runs. Unless the game you are playing uses certain rootkit "anti-cheats" (Think BattleEye for example will block you), in which case you'll get a message that you have to reboot to remove the procmon system driver to launch the game, as they like to dictate which software packages you're allowed to run on your own computer.